Sibutramine produces its therapeutic effects by norepinephrine, serotonin and dopamine reuptake inhibition. Sibutramine and its major pharmacologically active metabolites (M1 and M2) do not act via release of monoamines
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چکیده
Each MERIDIA capsule contains 5 mg, 10 mg, and 15 mg of sibutramine hydrochloride monohydrate. It also contains as inactive ingredients: lactose monohydrate, NF; microcrystalline cellulose, NF; colloidal silicon dioxide, NF; and magnesium stearate, NF in a hard-gelatin capsule [which contains titanium dioxide, USP; gelatin; FD&C Blue No. 2 (5and 10-mg capsules only); D&C Yellow No. 10 (5and 15-mg capsules only), and other inactive ingredients].
منابع مشابه
Sibutramine. A review of its contribution to the management of obesity.
Sibutramine is an orally administered centrally acting weight management agent apparently devoid of amphetamine-like abuse potential. Its primary (M2; BTS 54,505) and secondary (M1; BTS 54,354) amine metabolites are pharmacologically active and are thought to induce the natural processes leading to enhancement of satiety and thermogenesis by inhibiting serotonin (5-hydroxytryptamine, 5-HT) and ...
متن کاملAcute cardiovascular effects of sibutramine in conscious rats.
Sibutramine is a serotonin and norepinephrine reuptake inhibitor, used in the treatment of obesity. In this study, cardiovascular effects of sibutramine (0.9, 3, or 9 mg kg(-1) i.p.) were measured in conscious Sprague-Dawley rats, in the absence and presence of beta- and/or alpha-adrenoceptor antagonism (with propranolol and/or phentolamine, respectively). Sibutramine caused pressor and tachyca...
متن کاملSimultaneous thin-layer chromatography-densitometric analysis of sibutramine and citalopram.
Due the presence of sibutramine and citalopram in a number of drugs, neurotransmitter reuptake inhibitors. Sibutramine reduces the reuptake of serotonin, norepinephrine, and dopamine; citalopram is an antidepressant drug of the selective serotonin reuptake inhibitor. The thin-layer chromatography-densitometric behavior of some centrally acting serotonin reuptake inhibitors has been studied. The...
متن کاملA pilot study to evaluate the pharmacokinetics of sibutramine in healthy subjects under fasting and fed conditions.
PURPOSE The purpose of this study was to characterize the food effect on the pharmacokinetics of sibutramine and its pharmacologically active metabolites. METHODS This was an open label, single dose, crossover study completed by six healthy males. A single dose of sibutramine 15 mg was administered orally under fasting and fed conditions. Plasma concentrations of sibutramine and its metabolit...
متن کاملSibutramine in slimming food supplements on the Croatian market determined by validated high-pressure liquid chromatography- electrospray tandem mass spectrometry method
© 2016 National Agricultural and Food Centre (Slovakia) 1 Obesity is a complexed condition, with serious social and psychological dimensions, that affects virtually all age and socioeconomic groups and threatens to overwhelm both developed and develop ing countries. In 1995, there were an estimated 200 million of obese adults worldwide and another 18 million under-five children classified as ov...
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تاریخ انتشار 2010